Metronidazole and Neurological Concerns - Havanese Forum : Havanese Forums
 
LinkBack Thread Tools Display Modes
post #1 of 7 (permalink) Old 05-07-2013, 09:49 AM Thread Starter
Member
 
MayBTheresHope's Avatar
 
Join Date: Feb 2013
Location: Tennessee
Posts: 37
Submit Photo: 1
Photo Submissions 0 Times in 0 Posts
Metronidazole and Neurological Concerns

Hi All,

Miley is still battling Giardia. She has been on two rounds of Pancur (5 days, then off a week and back on again for 7 days). The next option that my vet is offering but has concerns about is Metrodinazole. He read a study once that said that it could cause neurological changes, but the dose tested was much higher than what Miley would be on.

I tried to research information about this and didn't really find anything significant. Does anyone here have any insight? I'm sooooo over the Giardia. I thought for sure that we had gotten rid of it this time, but no. Her poops are very much improved, though. I just the Giardia gone!
MayBTheresHope is offline  
Sponsored Links
Advertisement
 
post #2 of 7 (permalink) Old 05-07-2013, 10:17 AM
Member
 
Join Date: Mar 2012
Posts: 89
Submit Photo: 0
Photo Nominations 1 Time in 1 Post
Quote:
Originally Posted by MayBTheresHope View Post
Hi All,

Miley is still battling Giardia. She has been on two rounds of Pancur (5 days, then off a week and back on again for 7 days). The next option that my vet is offering but has concerns about is Metrodinazole. He read a study once that said that it could cause neurological changes, but the dose tested was much higher than what Miley would be on.

I tried to research information about this and didn't really find anything significant. Does anyone here have any insight? I'm sooooo over the Giardia. I thought for sure that we had gotten rid of it this time, but no. Her poops are very much improved, though. I just the Giardia gone!
I completely understand what you are going through with Giardia. I hate to even type that word! It took a while to get rid of it. The life cycle of Giardia is about two weeks, so many vets wait two weeks between the first and second dose of Panacur. We got rid of it when we did two doses of 5 days with two weeks apart - but I think the other big difference was that we added a daily probiotic. I would definitely recommend adding a "human grade" probiotic.

We tried Metrodinazole several times (with a former vet, whom we replaced when he couldn't provide any information about adding a probiotic). First of all, Metrodinazole (~40 - 60% effective) is less effective than Panacur (~70% effective) for treating Giardia. My Hav also had a bad reaction to Metrodinazole - we tried it and he threw up on the third day tried it (this happened on two separate occasions so we know it was the Metrodinazole) and also developed a strange twitching of his body which was a possible neurological side effect. Many vets LOVE to prescribe this stuff, feeling that it's a "wonder drug" for loose stools, but I agree with your vet's reservations. I wouldn't give it since it's less likely to get rid of Giardia anyway.

My suggestion would be to talk to your vet about giving another two round dose of Panacur and add a probiotic. It worked for us.

Good luck, I'm sure you will succeed. Giardia's got nothing on a determined Hav mommy ;-)
LJS58 is offline  
post #3 of 7 (permalink) Old 05-07-2013, 12:00 PM
Senior Member
 
HannahBearsMom's Avatar
 
Join Date: Jul 2011
Location: Northern Virginia
Posts: 531
Submit Photo: 5
Photo Submissions 6 Times in 6 Posts
Maccabee has been on Metrodinazole for 5 or 6 weeks (he's finished at the end of this week). I haven't seen any side effects, but he was in such bad shape when he started taking it that I wouldn't have noticed anyhow. What dose is being recommended for Miley? Maccabee started out on 1/4 of a 250 mg. tablet 2x day. The internist lowered his dose to 25 mg. twice a day (much more expensive because the smaller dose is not available at a regular pharmacy, only the vet). The vets at UT said we should discontinue the Metrodinazole at the end of the week or when we run out, whichever comes first.

Good luck! I hope Miley feels better soon.

___________________
Laurie

Starborn Light My Fire (Maccabee)


HannahBearsMom is offline  
 
post #4 of 7 (permalink) Old 05-07-2013, 07:17 PM
Senior Member
 
Pixiesmom's Avatar
 
Join Date: Jul 2008
Location: South Fla
Posts: 2,815
Submit Photo: 1
Photo Submissions 10 Times in 10 Posts
I put Mig on Parvaid and Kocci free when he has his giardia. There's a website called wolf creek ranch that I purchased it from. The manufacturer also has a website. I know some don't like the homeopathic route, but it's worth a try.

Beth, Pixie Puff and MiG too
Pixiesmom is offline  
post #5 of 7 (permalink) Old 05-07-2013, 07:39 PM
Senior Member
 
Missy's Avatar
 
Join Date: Nov 2006
Location: Massachusetts
Posts: 11,746
Submit Photo: 27
Photo Submissions 48 Times in 35 Posts
I can't speak for the canine side effects, but in humans the neurologics side effects happen with much higher doses and longer terms. I suspect he would be on the flagyl for 30 days tops. My experience is from treating and reading about lyme. I was on for a month and then a 2 week on 2 week off dose of flagyl for 4 months. I got some nerve pain in my feet, and on the third day of each 2 weeks on I got very depressed. All have disappeared since being off. It's not likely to make him feel great, but if it will get rid of the giardia, I think it would be worth the month of his feeling bad.




Missy, Jasper & Cash
Missy is offline  
post #6 of 7 (permalink) Old 05-08-2013, 02:38 PM Thread Starter
Member
 
MayBTheresHope's Avatar
 
Join Date: Feb 2013
Location: Tennessee
Posts: 37
Submit Photo: 1
Photo Submissions 0 Times in 0 Posts
Thanks for the replies, all. We are going to put her back on Panacur for 6 days and add 1/4 of a 250mg tablet Metrodinazole for 10 days to the mix, as well. I am going to was all of her bedding, toys and disinfect her ex-pen again and try to keep her as clean as possible. Hopefully, the 3rd time is a charm.
MayBTheresHope is offline  
post #7 of 7 (permalink) Old 05-08-2013, 03:50 PM
Metrowest, MA
 
krandall's Avatar
 
Join Date: Jun 2009
Location: Massachusetts
Posts: 23,604
Submit Photo: 6
Photo Submissions 298 Times in 296 Posts
Quote:
Originally Posted by MayBTheresHope View Post
Thanks for the replies, all. We are going to put her back on Panacur for 6 days and add 1/4 of a 250mg tablet Metrodinazole for 10 days to the mix, as well. I am going to was all of her bedding, toys and disinfect her ex-pen again and try to keep her as clean as possible. Hopefully, the 3rd time is a charm.
Make sure you're washing everything on the "hot" cycle. If the bedding and toys will take it, adding some bleach could help too.


Karen, Kodi, Pixel and Panda
(ARCHMX Starborn Kodak Moment CGC, NTD, BN, PCD, NA, NAJ, CDX-CCH, RE, RLV, RL1X3, RL2X4, RL3X3...
plus Starborn's Picture Perfect & Nauti Herd Compact Flash RN, CGC, NTD, SN-C, RL1)






krandall is offline  
Reply

Quick Reply
Message:
Options

Register Now



In order to be able to post messages on the Havanese Forum : Havanese Forums forums, you must first register.
Please enter your desired user name, your email address and other required details in the form below.

User Name:
Password
Please enter a password for your user account. Note that passwords are case-sensitive.

Password:


Confirm Password:
Email Address
Please enter a valid email address for yourself.

Email Address:
OR

Log-in










Thread Tools
Show Printable Version Show Printable Version
Email this Page Email this Page
Display Modes
Linear Mode Linear Mode



Posting Rules  
You may not post new threads
You may not post replies
You may not post attachments
You may not edit your posts

BB code is On
Smilies are On
[IMG] code is On
HTML code is Off
Trackbacks are On
Pingbacks are On
Refbacks are On

 
For the best viewing experience please update your browser to Google Chrome